A common genus of microbe found in wet, boggy environments could play a key role in the development of Parkinson's disease, by excreting compounds that trigger proteins inside brain cells to form toxic clumps.
在潮湿的沼泽环境中发现的一种常见微生物可能在帕金森病的发展中发挥关键作用,通过分泌触发脑细胞内蛋白质形成有毒团块的化合物。
The findings, made by a small team of researchers at the University of Helsinki and the University of Eastern Finland, build on the results of an earlier investigation showing that the severity of the neurodegenerative disorder in volunteers increased with concentrations of Desulfovibrio bacterial strains in their feces.
赫尔辛基大学和东芬兰大学的一个研究小组的研究结果建立在早期调查结果的基础上,该结果显示,志愿者的神经退行性疾病的严重程度随着粪便中脱硫弧菌菌株的浓度而增加。
By now demonstrating a potential path from the presence of the bacteria in genetically edited worms to physical changes in the brain that coincide with Parkinson's disease, the researchers hope to one day improve early diagnosis of the disease in humans, or even slow its progress.
通过现在展示从基因编辑蠕虫中细菌的存在到与帕金森病相一致的大脑物理变化的潜在途径,研究人员有望能够改善这一疾病的早期诊断,甚至减缓其进展。
"Our findings make it possible to screen for the carriers of these harmful Desulfovibrio bacteria," says senior author Per Saris, a microbiologist at the University of Helsinki in Finland.
“我们的研究结果使筛选这些有害的脱硫弧菌细菌的携带者成为可能,”资深作者,芬兰赫尔辛基大学微生物学家Per Saris说。
"Consequently, they can be targeted by measures to remove these strains from the gut, potentially alleviating and slowing the symptoms of patients with Parkinson's disease."
“因此,它们可以通过措施将这些菌株从肠道中去除,从而可能减轻和减缓帕金森病患者的症状。“