Researchers from a new 2023 study published in The Lancet looked at the single-cell makeup of immune cells in the blood of seven individuals with an average age of 106. They compared their genetic profile to the cells of seven alternate centenarians and more than 50 people between the ages of 20 and 89. They obtained this comparison data through public databases containing the patients' single-cell genetic sequencing.

发表在《柳叶刀》杂志上的一项2023年新研究的研究人员,研究了7名平均年龄为106岁的人血液中免疫细胞的单细胞组成.他们将这些人的基因图谱与7位百岁老人和50多名年龄在20岁至89岁之间的人的细胞进行了比较.他们通过包含患者单细胞基因测序的公共数据库获得了这些比较数据.

The research findings revealed that the study participants' immune cell profiles did not appear to have undergone the typical transformations associated with aging. For many people, it's these natural changes that often lead to gradual immune system decline in older adulthood.

研究结果显示,研究参与者的免疫细胞图谱似乎没有经历与衰老相关的典型转变.对许多人来说,正是这些自然变化导致了老年人免疫系统的逐渐衰退.

"What we basically found is that centenarians manifest a history of exposure to natural environmental immunogens that made them more resilient and more resistant to potential harmful factors," co-researcher on the study Dr. Stefano Monti told HealthDay. Not only that, but the study team also identified the heightened expression of one particular gene associated with fighting off DNA damage as a factor in longevity.

"我们基本上发现,百岁老人表现出暴露于自然环境免疫原的历史,使他们更有弹性,更能抵抗潜在的有害因素,"该研究的联合研究员斯特凡诺·蒙蒂博士告诉《每日健康》.不仅如此,研究小组还发现,一种与对抗DNA损伤有关的特定基因的表达增加是长寿的一个因素.

While the research may potentially shed some light on one factor that may contribute to a prolonged lifespan, some experts state that there are too many confounding variables that contribute to longevity, therefore making it difficult to isolate causation. This can include family medical history, healthy lifestyle habits, and more.

虽然这项研究可能会揭示一个可能有助于延长寿命的因素,但一些专家表示,有太多影响寿命的混杂变量,因此很难分离出因果关系.包括家族病史、健康的生活习惯等等.