In cases with cardiac ischemia , rather than necrosis , it may be more difficult to confirm the diagnosis when the patient has acute chest pain , non-diagnostic electrocardiograms ( ecg ) , and normal biomarkers for necrosis .
In addition , coagulated tissue acts as a barrier to further penetration of acid ( coagulation necrosis ) .
除此之外,凝固的组织也可作为屏障防止酸的进一步渗透(凝固性坏死)。
Hydroxyl ions induce saponification of cell membranes and cell death along with disruption of the extracellular matrix ( liquifaction necrosis ) .
氢氧根离子可诱发细胞膜的皂化反应和细胞死亡,且同时可破坏细胞外基质(液化性坏死)。
They are reported to serve as biological response modifiers with the capability to activate macrophages and t-cells , and to produce cytokines , interleukins and tumor necrosis factors .
From a diagnostic standpoint , the aim is to try and develop biomarkers that identify patients with acs , even when there is no evidence of myocyte necrosis .