Temporal lobe epilepsy and some predisposing factors , such as : fever , infection , fatigue , alcohol consumption , alcohol withdrawal , pregnancy and childbirth , disable sedatives , isoniazid , tricyclic or tetracyclic antidepressants can also induce .
Using acyclovir as raw material , two novel tricyclic derivatives of guanine analogue were synthesized through the reaction of cyclization , esterification and alkylation .