It is important to look for sensitive and objective UMN makers , because they can not only assist diagnosis and disease monitoring , but also help to screen early ALS patients into the clinical trials of emerging treatments and establish economical effect assessment indices .
Objective : To investigate the transcranial magnetic stimulation motor evoked potential ( TMS-MEP ) changes in amyotrophic lateral sclerosis ( ALS ) and their correlations with clinical aspects . To assess the value of TMS-MEP in the diagnosis and upper motor neuron ( UMN ) lesion evaluations of ALS .
Results show that E_c increased with the increase of energy input and the increase of the ratio of annular width to col - umn diameter .
结果表明,环形柱内连续相轴向扩散系数E_c随外界输入能量的增大而增大,随隙径比的增大而增大。
Conclusion The results from 1H-MRS suggest the distribution of neuronal loss in ALS , and 1H-MRS can be a quantitative measurement in the evaluation of UMN dysfunction in ALS .
Object : To analyze whether the UMN could be used as a tumor marker in diagnosing lung cancer , and evaluating therapy effect and monitoring prognosis of lung cancer patients .
Objective : To investigate the TMS-MEP changes in ALS and their correlations with clinical aspects . To assess the value of TMS-MEP in the diagnosis and UMN lesion evaluations of ALS .