The microscopic brain abnormalities associated with the disease include clumps of proteins called amyloid plaques and tangles of another protein called tau .
与这种疾病有关的大脑微观结构的畸变,包括称为淀粉样蛋白斑块和另一种称为tau蛋白缠结。
Since 1991 the smart money has been on the hypothesis that the disease is caused by the plaques , and that the tangles are mere consequence .
自1991年起,投资的钱一直下注在假设该病是因各种斑而起与那些缠结仅是附带产生而已。
Researchers have been pursuing treatments that would normalize amyloid metabolism in the brain and rid neurons of the tau tangles that cripple their function .
And , crucially , a lack of insulin or insulin resistance is connected both to amyloid protein regulation and to the modification of tau proteins , which can cause tangles .