Objective To observe the effects of tiopronin ( MPG ) on the prevention and treatment of leukocytopenia induced by radiotherapy in mice .
为观察硫普罗宁(Tiopronin,MPG)对放疗所致小鼠白细胞减少的预防和治疗作用。
Aim : To observe the effect of tiopronin ( MPG ) in the prevention and treatment of leukocytopenia induced by chemotherapy in mice .
目的:观察硫普罗宁(Tiopronin,MPG)对化疗所致小鼠白细胞减少的预防和治疗作用。
Methods The positive rate of granulocyte associated antibody ( Igs ) was determined with flowcytometry in 345 patients with leukocytopenia and 60 controls .
Grade 3 leukocytopenia occurred in 18 . 8 % of the patients , and grade 3 thrombocytopenia in 28 . 0 % during therapy .
治疗中,18.0%和28.0%的患者分别出现了Ⅲ级白细胞和血小板减少。
The main toxicity was marrow suppression . The rate of leukocytopenia and thrombocytopenia with ⅲ to ⅳ degree was 37.1 % and 25.9 % respectively .
毒性反应以骨髓抑制为主,Ⅲ~Ⅳ度白细胞下降为37.1%,Ⅲ~Ⅳ度血小板下降为25.9%。
The morphological characters in 50 patients with leukocytopenia were mainly the decrease of granulocytes , increase of monocytes and lymphocytes , and toxic granules in neutrophils .
Methods : Although leukocytopenia is to do with 5 organs , but from the view of cause and mechanism , it is closely related to spleen and kidney .
方法:白细胞减少症虽与五脏有关,但与脾肾关系最为密切。
In the control group , leukocytopenia incidence is 53.3 % , vomiting incidence 66.7 % , hepatic function lesion incidence 20 % , still alopecia and neurologic toxicities occurred .
Results Frequencies of leukocytopenia , vomiting , asthenia and anorexia in the treatment group were all lower than those in the control group with significance ( P < 0.05 ) .