Oliver and her colleagues set out to study cisplatin resistance in mice with a mutation in a gene called kras , which leads the animals to develop lung cancer .
While cisplatin is often effective when first given , it has a major drawback : tumors can become resistant to the drug and start growing again .
顺铂通常第一次给药时有效,它有一个主要的缺陷:肿瘤获得耐药性,而且重新开始生长。
This study represents an important step toward better understanding of how cisplatin resistance arises , says thomas helleday , professor of radiation oncology at the university of oxford , who was not involved in the research .
When pidd levels are artificially increased in human lung cancer cells , they become more resistant to cisplatin .
当pidd水平在肺癌细胞人为增加时,它们对顺铂耐药性增强。
After four doses of cisplatin , mice with normal p53 developed resistance to the drug , and tumors started growing faster .
在四个顺铂剂量之后,有正常p53的小鼠获得了药物的耐药性,肿瘤开始加速生长。
Now , mit cancer biologists have shown how that resistance arises , a finding that could help researchers design new drugs that overcome cisplatin resistance .
The researchers found that cisplatin was effective against lung tumors in both sets of mice , though it was more potent in mice that still had functional p53 .