first and last Altogether; on the whole; primarily; above all （考虑到一切因素）总的说来，整体看来;主要地;完全 First and last, be sure to be true to your own desires. 说到底，你都要忠于你自己的意愿。 The book is, first and last, an account of a poet's development. 这本书，说到底，就是对一位诗人发展的记述。 千万不要和from first to last记混， from first to last的意思是"从始至终（from start to finish）" 或者是 "贯穿（throughout）" We cheered them on from first to last. 我们自始至终为他们加油。